function:Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.,PTM:Phosphorylation probably regulates the interaction with NSH2.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly located at podocyte slit diaphragm.,subunit:Interacts with NPHS1/nephrin, TJP1/ZO-1 and C-terminus of NPHS2/podocin.,tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.,
Cell membrane ; Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm.
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
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