function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.,similarity:Belongs to the profilin family.,subunit:Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.,tissue specificity:Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.,
Cytoplasm, cytoskeleton.
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
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