domain:MVP 3 mediates interaction with PTEN.,domain:MVP 4 mediates interaction with PARP4.,function:Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.,induction:Up-regulated by IFNG.,PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on Tyr residues after EGF stimulation.,similarity:Contains 9 MVP (vault) repeats.,subcellular location:5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.,subunit:The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 Mda, it consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC.,tissue specificity:Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.,
Cytoplasm . Nucleus, nuclear pore complex . Cytoplasm, perinuclear region . 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
下载说明书
