function:Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.,induction:By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).,similarity:Belongs to the SLC29A transporter family.,tissue specificity:Expressed in placenta, brain, heart and ovarian tissues.,
Basolateral cell membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein . Localized at the basolateral cell membrane in polarized MDCK cells.
Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.
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