caution:The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is uncertain. The alleles could not be confirmed in further studies (PubMed:12445303).,function:Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.,polymorphism:The following alleles of E-1 are known: E*0101, E*0102, E*0103 and E*0104. The sequence shown is that of E*0101.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).,
Cell membrane ; Single-pass type I membrane protein. Golgi apparatus membrane .; [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted .
Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level).
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