KLOT Polyclonal Antibody

catalytic activity:A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol.,disease:Defects in KL may be a cause of chronic renal failure complications.,domain:Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 239, and the second one lacks the essential Glu active site residue at position 872.,function:May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D.,function:The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.,online information:The thread of life -Issue 65 of December 2005,polymorphism:Homozygosity for KL-VS allele is associated with decreased longevity and increased cardiovascular disease risk.,PTM:N-glycosylated.,similarity:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,subcellular location:Isoform 1 shedding leads to a soluble peptide.,subunit:Homodimer.,tissue specificity:Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.,