function:Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Chimeric cDNA.,similarity:Contains 1 DZF domain.,subunit:Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80.,
Nucleus, nucleolus. Cytoplasm . Nucleus . Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Fetal liver,Lung,Thymus,
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