catalytic activity:2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.,disease:Defects in GPX4 may be a cause of infertility.,function:Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.,similarity:Belongs to the glutathione peroxidase family.,subunit:Monomer. Has a tendency to form higher mass oligomers.,tissue specificity:Present primarily in testis.,
[Isoform Mitochondrial]: Mitochondrion .; [Isoform Cytoplasmic]: Cytoplasm .
Present primarily in testis. Expressed in platelets (at protein level) (PubMed:11115402).
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