function:Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).,subcellular location:May be partially nuclear.,subunit:Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.,
Cytoplasm . Nucleus . May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.
Epithelium,Hypothalamus,Placenta,Spleen,
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