catalytic activity:D-glucose 6-phosphate + H(2)O = D-glucose + phosphate.,disease:Genetic variation in G6PC2 is associated with fasting plasma glucose levels quantitative trait locus type 1 (FGQTL1) [MIM:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.,function:May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis.,pathway:Carbohydrate biosynthesis; gluconeogenesis.,PTM:N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.,similarity:Belongs to the glucose-6-phosphatase family.,tissue specificity:Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).,
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).
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