domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,sequence caution:Intron retention.,similarity:Belongs to the SPSB family.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts with MET.,
intracellular,
Brain,Eye,Hypothalamus,Testis,
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