DEAF1 rabbit pAb

alternative products:Experimental confirmation may be lacking for some isoforms,caution:This protein was first known as suppressin (characterized in bovine neuroendocrine and immune cells). However, according to PubMed:9773984, it is uncertain whether it corresponds really to the suppressin also described in Ref.3. DEAF1 has been described as a nuclear dimeric protein and suppressin as a secreted monomeric protein.,disease:Defects in DEAF1 could confer a growth advantage to the mutated cell that may have implications for the development and progression of neoplasia, e.g. in the case of colorectal adenocarcinomas (CRC).,function:Transcription factor that binds to sequence with multiple copies of TTC[CG]G present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.,miscellaneous:Subcellular location in CRC (cytoplasmic or nuclear) is a prognostic factor that identifies a subgroup of patients with reduced survival. In addition, changes in the subcellular location correlates with the proliferative status of the cells.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 SAND domain.,subcellular location:Cytoplasmic in non-mucinous colorectal carcinoma.,subcellular location:Secreted in some cell types.,subunit:Homodimer (Probable). Binds to LMO4 (via its C-terminus), LMO2 and CLIM2 (By similarity). May interact with the corepressor NCOR.,tissue specificity:Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells.,