developmental stage:Expressed in fetal kidney, cochlea, eye, heart and lung.,domain:The MAM domain is required for localization at the cell surface.,function:Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.,similarity:Belongs to the nephronectin family.,similarity:Contains 1 MAM domain.,similarity:Contains 5 EGF-like domains.,subcellular location:Trapped on the cell surface or in the extracellular matrix.,subunit:Homodimer and homotrimer.,tissue specificity:Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.,
Secreted, extracellular space, extracellular matrix . Trapped on the cell surface or in the extracellular matrix. .
Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
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